2016_Head & Neck COURSE BOOK

EORTC/DAHANCA 29 randomized phase III

Role of Nimorazole in chemo‐radiation of HPV neg HNSCC

LARYNX PHARYNX* ,  HPVneg (p16); Stage 3‐4 (T2‐4,N0‐3)

* Except NPC

Stratify:

Accl RT(6 fx/wk) +cisPl

Stage Site

640 patients – (>200 with positive hypoxic gene profile).  Pi t l t i l t t bli h th t i di ti f Ni l i vo a r a o es a s e rue n ca on o morazo e n  Chemoradiotherapy of advanced HNSCC and the value of the hypoxic  gene profile

Inst. Hypox.  Gene profile  (retro specti e) ‐ v

OMIZE

RAND

Accl RT(6 fx/wk) +cisPl

+ Nimorazole  (1.2 g/m2)