2016_Head & Neck COURSE BOOK

Conclusions hypoxia – • A significant proportion of HN squamous cell carcinomas contains hypoxic regions • Patients with hypoxic tumours have poorer loco‐regional control and survival • Hypoxic modification (sensitizers, HBO,  hypoxic cytotoxins) during RT results in  improved loco‐regional control and survival • Predictive assays, hypoxic imaging and  dosepainting is emerging but still  investigational