September 2015 SPADA Meeting

Background

• Staphylococcal enterotoxins are pyrogenic  proteins that lead to toxic shock and respiratory  distress due to inhalation. • Symptoms 90 minutes‐24 hours post aerosol  exposure fever, headache, muscle aches,  pulmonary and GI symptoms. • Biothreat agent due to universal availability and  lack of discernment between other syndromes  or diseases. • Initial aerosol exposure studies performed with  SEB only, SEA & SEC shown later to have similar  effects.

SMPR Key Points

• Field use by DOD trained operators  • Analytical protein detection method in  liquid samples of SEA, SEB, SEC 1 , SEC 2 ,&  SEC 3 . • Acceptable minimum detection level  (AMDL) of 0.25ng/mL with a maximum time  t lt f f h o resu o our ours. • Probability of detection (POD) of the  analyte shall be > 0.95.