URI_Research_Magazine_2011-2012_Melissa-McCarthy

Daniel Udwary, Navindra Seeram and David Rowley

NATURAL PRODUCTS GROUP

In the world of science, new frontiers can sometimes be found ready- made, right in the natural world around us. At least this has been the case for a group of scientists in the University of Rhode Island’s (URI) College of Pharmacy, their big ideas in research are making waves with their discoveries of natural beneficial health products in everything from the oceans to the forests – they are exploring marine microorganisms to maple syrup. Their hands-on innovation can change the pharmacological world and hopefully lead to new economic strides in the health care industry. Discovering medicinal substances in marine and terrestrial plants and other natural sources is called pharmacognosy and URI has been known for its research in this field since 1957, when the College of Pharmacy opened. But in recent years, the university has intensified its commitment to this branch of pharmacy with the addition of three passionate professors, who are taking URI’s reputation for natural products research to a whole new level. They call themselves the Natural Products Group and they represent three very different, yet very complementary, facets of pharmacognosy. David Rowley, an associate professor of biomedical and pharmaceutical sciences, looks to the ocean as a source for new drugs. Specifically, he studies marine microbes in the hopes of creating new healing agents, following a tradition at URI that dates back to 1966, when the College of Pharmacy partnered with URI’s Graduate School of Oceanography to launch a “Drugs from the Sea” research program.

“We’ve been isolating microbes from deep sea mud, with the hope that we can develop new antibiotics,” said Rowley. The idea behind ocean pharmacognosy is to find disease-fighting agents in previously unexplored environments, which is why the mud Rowley is studying comes from a remote region of the South Pacific. So far, preliminary results are promising, he said, noting that the microbes he has discovered are “perhaps unlike any others that have been investigated.” Rowley is also researching the chemistry of bacteria that promote disease-resistance in oysters and other organisms of interest to the aquaculture industry. Rowley’s research has been funded by grants from the National Oceanic and Atmospheric Administration, the National Science Foundation and the Rhode Island Science & Technology Advisory Council. Additionally, Ocean Spray Cranberries, Inc., has funded work Rowley is doing into the beneficial agents found in cranberries. But terrestrial research is not the norm for Rowley. “Most of my work is marine-related,” he said. Not so with College of Pharmacy assistant professor Navindra Seeram, whose research into pomegranates, berries and, most recently, maple syrup has generated considerable excitement in the field of pharmacognosy. “I work with plants that people eat,” said Seeram, who came to URI

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