2017 Sec 1 Green Book

TABLE 4 Effect Modi fi cation on Change: Weight Category (Normal Versus Overweight Versus Obese) Outcome eAT

P a

P b

WWSC

Normal

Overweight

Obese

Normal

Overweight

Obese

Peds QL (parent) total Peds QL (child) total

5.54 6 1.33 5.11 6 1.73

1.91 6 1.61 0.86 6 2.06

4.09 6 2.31 5.22 6 2.94

2 0.00 6 1.24 4.64 6 1.65 2 4.19 6 1.68 2 0.03 6 0.02 2 0.11 6 0.03 2 0.04 6 0.03 0.02 6 0.03 2 0.20 6 0.39

2 2.58 6 1.56 2 0.14 6 2.06 2 2.33 6 2.08 2 0.00 6 0.02 2 0.05 6 0.04 2 0.02 6 0.04 2 0.03 6 0.04 2 0.41 6 0.48

2 0.63 6 2.33 .99 .91 1.27 6 3.03 .89 .74 2 1.14 6 3.11 .79 .96 2 0.01 6 0.03 .92 .76 2 0.08 6 0.06 .89 .92 0.08 6 0.06 .32 .36 2 0.06 6 0.05 .10 .13 0.13 6 0.72 .12 .09

OSA-18 total

2 21.23 6 1.77 2 0.28 6 0.02 2 0.65 6 0.03 2 0.28 6 0.03 2 0.12 6 0.03 2 2.37 6 0.41

2 18.57 6 2.14 2 0.24 6 0.02 2 0.59 6 0.04 2 0.26 6 0.04 2 0.12 6 0.04 2 1.14 6 0.50

2 18.70 6 3.19 2 0.24 6 0.03 2 0.59 6 0.06 2 0.28 6 0.06 2 0.04 6 0.05 2 2.77 6 0.72

PSQ-SRBD total

PSQL snoring subscale PSQL sleepiness subscale PSQL behavior subscale

SLSC total (mESS)

Data are presented as mean 6 SD; marginal means adjusting for variables included in P value 1. a P value for interaction term adjusting strati fi ed variables only: site, race (African American versus non – African American), and age (5 – 7 vs 8 – 10 years old). b P value for interaction term adjusting for site, race (African American versus non – African American), age (continuous), gender, maternal education (less than high school, high school or higher, or missing/not sure), income ( . $30 000, # $30 000, and missing), baseline log AHI, and baseline outcome variable.

substantially more after eAT than WWSC. Bene fi ts from eAT were evident in generic and disease- speci fi c health-related QoL (as measured by using the PedsQL and OSA-18) and in OSAS symptoms (as re fl ected by using the PSQ SRBD scale and the mESS). Moderate to large improvements were observed for most QoL and symptom measurements, including the parent- completed PedsQL (total score, school, emotional, and physical function domains), OSA-18 (total and all 5 domains), mESS, and the PSQ SRBD (total score and snoring, sleepiness, and inattentive/ behavioral subscales). Improvement in OSAS severity measured by using PSG variables explained only a small proportion of the improvements seen in OSAS symptoms and QoL. These observations have important clinical implications for the many children

well supported by the current literature for either neurobehavioral morbidity or QoL. 19,26 Previous studies of children with OSAS have shown no association between baseline OSA-18 scores and severity of OSAS on PSG. 32 Moreover, studies have failed to demonstrate clear correlation between extent of PSG improvements after AT and improvement in QoL. 33,34 In CHAT, we observed correlations between changes in AHI or ODI and changes in QoL and symptom severity measures. However, PSG improvements explained only a small portion of the variance for the change scores (partial r 2 ranging from , 0.01 to 0.17). Thus, both previous literature and current data indicate that using PSG results as the sole metric for effectiveness of AT in pediatric OSAS may neglect other bene fi ts that are important to children and their families.

with OSAS who are evaluated for AT. The fi ndings are of particular relevance, given the growing interest from patients, payers, and providers that QoL and symptom outcomes be highlighted in the management of considered when making a decision to perform surgery or to judge the success of surgical interventions. Previous studies measuring success rates for AT in children with OSAS have often focused somewhat narrowly on normalization of PSG parameters, with reports of surgical success rates ranging from 27% to 83%; lower cure rates are typically reported in obese children. 19,28 – 31 This emphasis on PSG measures of disease resolution may be partially due to assumptions that PSG severity parallels severity of the symptoms seen with OSAS. This concept is not chronic health conditions. Clinically, many factors are

TABLE 5 Effect Modi fi cation on Change: Race (African American Versus Non – African American) Outcome eAT

P a

P b

WWSC

African American

Non – African American

African American

Non – African American

Peds QL (parent) total Peds QL (child) total

3.18 6 2.07 4.55 6 2.50

7.44 6 1.82 0.85 6 2.17

2 0.12 6 2.47 3.09 6 3.03 2 10.71 6 3.36 2 0.10 6 0.03 2 0.23 6 0.06 2 0.07 6 0.07 2 0.06 6 0.05 2 0.90 6 0.72

2.12 6 2.22 2.44 6 2.65 2 5.07 6 3.03 2 0.07 6 0.03 2 0.25 6 0.06 2 0.02 6 0.06 2 0.03 6 0.05 2 0.91 6 0.65

.57 .48 .04 .01 .91 .03

.77 .26 .09 .01 .79 .26

OSA-18 total

2 17.85 6 2.84 2 0.23 6 0.03 2 0.67 6 0.05 2 0.13 6 0.06 2 0.01 6 0.04 2 1.67 6 0.60

2 22.51 6 2.51 2 0.32 6 0.02 2 0.68 6 0.05 2 0.29 6 0.05 2 0.18 6 0.04 2 2.57 6 0.53

PSQ-SRBD total

PSQL Snoring sub-scale PSQL Sleepiness sub-scale PSQL Behavior sub-scale

, .01

, .01

.40

.32

SLSC total (mESS)

Data are presented as mean 6 SD; marginal means adjusting for variables included in P value 1. a P value for the effect modi fi cation adjusting for strati fi ed variables only: site, age (5 – 7 vs 8 – 10 years old), and overweight ( $ 85th vs , 85th BMI percentile). b P value for the effect modi fi cation adjusting for site, age (continuous), obese ( , 95 vs $ 95 BMI percentile), gender, maternal education (less than high school, high school or higher, or missing/not sure), income ( . $30 000, # $30 000, or missing), baseline log AHI, and baseline outcome variable.

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