Lower GI 2016

cT1-2/3 low

Local Excision

5 x 5 Gy + 4 Gy Boost

4-8 weeks

Polish prospective multicenter study: n= 64 ypT0-1: 67%; Local recurrence (2y) 12%

Bujko et al., Radiother Oncol 2013

6 cycles of CAPOX + Bevacizumab

cTx M1

5 x 5 Gy

Surgery

Dutch M1-trial: n= 50 pCR 26%, radical operation/ablation of all tumor sites (R0) in 72%

Van Dijk et al., Ann Oncol 2013