Lower GI 2016

The TIMING Trial

6 wks

T M E

RT 50.4 Gy/1.8Gy 5-FU 225 mg/m 2

Group 1

T M E

4 wks

4 wks

mFOLFOX6 2#, q15

RT 50.4 Gy/1.8Gy 5-FU 225 mg/m 2

Group 2

T M E

4 wks

4 wks

mFOLFOX6 4#, q15

RT 50.4 Gy/1.8Gy 5-FU 225 mg/m 2

Group 3

T M E

4 wks

4 wks

mFOLFOX6 6#, q15

RT 50.4 Gy/1.8Gy 5-FU 225 mg/m 2

Group 4

Garcia-Aquilar J et al, Lancet Oncol 2015