NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

2012;379:633-640. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22257673 .

Clin Oncol 1998;16:2672-2685. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9704717 . 158. Bear HD, Anderson S, Smith RE, et al. Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 2006;24:2019-2027. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16606972 . 159. Hudis C, Modi S. Preoperative chemotherapy for breast cancer: miracle or mirage? JAMA 2007;298:2665-2667. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18073362 . 160. Buzdar AU, Ibrahim NK, Francis D, et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 2005;23:3676-3685. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15738535 . 161. Buzdar AU, Valero V, Ibrahim NK, et al. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 2007;13:228-233. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17200359 . 162. Untch M, Loibl S, Bischoff J, et al. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol 2012;13:135-144. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22257523 . 163. Baselga J, Bradbury I, Eidtmann H, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet

164. Piccart-Gebhart M, Holmes A, de Azambuja E, et al. The association between event-free survival and pathological complete response to neoadjuvant lapatinib, trastuzumab or their combination in HER2-positive breast cancer. Survival follow-up analysis of the NeoALTTO study (BIG 1-06). [abstract]. Program and abstracts of the 2013 San Antonio Breast Cancer Symposium; December 10-14, 2013; San Antonio, Texas. :Abstract S1-01. Available at: http://sabcs.org/PressReleases/Documents/2013/b5471154c8455fa6.p df . 165. Scheuer W, Friess T, Burtscher H, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res 2009;69:9330-9336. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19934333 . 166. Baselga J, Cortes J, Im S-A, et al. Biomarker analyses in CLEOPATRA: A phase III, placebo-controlled study of pertuzumab in HER2-positive, first-line metastatic breast cancer (MBC). Cancer Research 2012;72:S5-1. Available at: http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/72/24_M eetingAbstracts/S5-1 . 167. Swain S, Kim S-B, Cortes J, et al. Confirmatory overall survival (OS) analysis of CLEOPATRA: a randomized, double-blind, placebo- controlled Phase III study with pertuzumab (P), trastuzumab (T), and docetaxel (D) in patients (pts) with HER2-positive first-line (1L) metastatic breast cancer (MBC). Cancer Research 2012;72:P5-18-26. Available at: http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/72/24_M eetingAbstracts/P5-18-26 . 168. Schneeweiss A, Chia S, Hickish T, et al. Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline- containing and anthracycline-free chemotherapy regimens in patients

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