NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

225. Romond E, Suman V, Jeong J-H, et al. Trastuzumab plus adjuvant chemotherapy for HER2-positive breast cancer: Final planned joint analysis of overall survival (OS) from NSABP B-31 and NCCTG N9831. Cancer Research 2012;72:S5-5. Available at: http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/72/24_M eetingAbstracts/S5-5 . 226. Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365:1273-1283. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21991949 . 227. Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-2648. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10561337 . 228. Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11248153 . 229. Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2- overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719- 726. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11821453 . 230. Jeffrey SS, Lonning PE, Hillner BE. Genomics-based prognosis and therapeutic prediction in breast cancer. J Natl Compr Canc Netw 2005;3:291-300. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16002001 . 231. Perou CM, Jeffrey SS, van de Rijn M, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A 1999;96:9212-9217. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10430922 .

232. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-10874. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11553815 . 233. Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 2003;100:8418-8423. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12829800 . 234. Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004;351:2817-2826. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15591335 . 235. Paik S, Tang G, Shak S, et al. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol 2006;24:3726-3734. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16720680 . 236. Fan C, Oh DS, Wessels L, et al. Concordance among gene- expression-based predictors for breast cancer. N Engl J Med 2006;355:560-569. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16899776 . 237. Wang Y, Klijn JGM, Zhang Y, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast 238. Glas AM, Floore A, Delahaye LJMJ, et al. Converting a breast cancer microarray signature into a high-throughput diagnostic test. BMC Genomics 2006;7:278-278. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17074082 . 239. van de Vijver MJ, He YD, van't Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med cancer. Lancet 2005;365:671-679. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15721472 .

Version 2.2015, 03/11/15 © National Comprehensive Cancer Network, Inc. 2015, All rights reserved. The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®. MS-83

Made with