NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

pharmacologic interventions including tamoxifen, raloxifene, and aromatase inhibition for breast cancer risk reduction. J Clin Oncol 2009;27:3235-3258. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19470930 . 319. Erban JK, Lau J. On the toxicity of chemotherapy for breast cancer--the need for vigilance. J Natl Cancer Inst 2006;98:1096-1097. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16912256 . 320. Henderson I, Berry D, Demetri G, et al. Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J Clin Oncol 2003;21:976-983. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12637460 . 321. Mamounas E, Bryant J, Lembersky B, et al. Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28. J Clin Oncol 2005;23:3686-3696. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15897552 . 322. Citron ML, Berry DA, Cirrincione C, et al. Randomized trial of dose- dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol 2003;21:1431-1439. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12668651 . 323. Sparano JA, Wang M, Martino S, et al. Phase III study of doxorubicin-cyclophosphamide followed by paclitaxel or docetaxel given every 3 weeks or weekly in patients with axillary node positive or high risk node negative breast cancer [abstract]. San Antonio Breast Cancer Symposium 2005:Abstract 48. Available at: 324. Sparano JA, Wang M, Martino S, et al. Phase III study of doxorubicin-cyclophosphamide followed by paclitaxel or docetaxel given every 3 weeks or weekly in operable breast cancer: Results of

Intergroup Trial E1199 [abstract]. J Clin Oncol 2007;25 (Suppl_18) Abstract 516. Available at: http://meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/516 . 325. Sparano J, Wang M, Martino S, et al. Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med 2008;358:1663- 1671. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18420499 . 326. Jones S, Holmes FA, O'Shaughnessy J, et al. Docetaxel with cyclophosphamide is associated with an overall survival benefit compared with doxorubicin and cyclophosphamide: 7-year follow-up of US Oncology Research trial 9735. J Clin Oncol 2009;27:1177-1183. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19204201 . 327. Bang SM, Heo DS, Lee KH, et al. Adjuvant doxorubicin and cyclophosphamide versus cyclophosphamide, methotrexate, and 5- fluorouracil chemotherapy in premenopausal women with axillary lymph node positive breast carcinoma. Cancer 2000;89:2521-2526. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11135211 . 328. Fisher B, Anderson S, Tan-Chiu E, et al. Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23. J Clin Oncol 2001;19:931-942. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11181655 . 329. Fisher B, Brown AM, Dimitrov NV, et al. Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen- nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15. J Clin Oncol 1990;8:1483-1496. Available at: http://www.ncbi.nlm.nih.gov/pubmed/2202791 . 330. Fisher B, Anderson S, Wickerham DL, et al. Increased intensification and total dose of cyclophosphamide in a doxorubicin- cyclophosphamide regimen for the treatment of primary breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-22.

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