NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

J Clin Oncol 1997;15:1858-1869. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9164196 .

337. Benefit of a high-dose epirubicin regimen in adjuvant chemotherapy for node-positive breast cancer patients with poor prognostic factors: 5-year follow-up results of French Adjuvant Study Group 05 Randomized Trial. J Clin Oncol 2001;19:602-611. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11157009 . 338. Piccart MJ, Di Leo A, Beauduin M, et al. Phase III trial comparing two dose levels of epirubicin combined with cyclophosphamide with cyclophosphamide, methotrexate, and fluorouracil in node-positive breast cancer. J Clin Oncol 2001;19:3103-3110. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11408507 . 339. Ellis P, Barrett-Lee P, Johnson L, et al. Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial. Lancet 2009;373:1681-1692. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19447249 . 340. Martin M, Rodriguez-Lescure A, Ruiz A, et al. Randomized phase 3 trial of fluorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancer. J Natl Cancer Inst 2008;100:805-814. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18505968 . 341. Martin M, Pienkowski T, Mackey J, et al. Adjuvant docetaxel for node-positive breast cancer. N Engl J Med 2005;352:2302-2313. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15930421 . 342. Swain SM, Jeong J-H, Geyer CE, et al. NSABP B-30: definitive analysis of patient outcome from a randomized trial evaluating different schedules and combinations of adjuvant therapy containing doxorubicin, docetaxel and cyclophosphamide in women with operable, node-positive breast cancer [abstract]. Cancer Research 2009;69 (Suppl_1):Abstract 75. Available at: http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/69/2_Me etingAbstracts/75 .

331. Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 1998;352:930-942. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9752815 . 332. Wood WC, Budman DR, Korzun AH, et al. Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma. N Engl J Med 1994;330:1253-1259. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8080512 . 333. Menard S, Valagussa P, Pilotti S, et al. Response to cyclophosphamide, methotrexate, and fluorouracil in lymph node- positive breast cancer according to HER2 overexpression and other tumor biologic variables. J Clin Oncol 2001;19:329-335. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11208823 . 334. Muss HB, Thor AD, Berry DA, et al. c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N Engl J Med 1994;330:1260-1266. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7908410 . 335. Watanabe T, Kuranami M, Inoue K, et al. Phase III trial comparing 4-cycle doxorubicin plus cyclophosphamide followed by 4-cycle taxan with 8-cycle taxan as adjuvant therapy for node-positive breast cancer: Results of N-SAS-BC02 trial [abstract]. J Clin Oncol 2009;27(Suppl 15):Abstract 516. Available at: http://meeting.ascopubs.org/cgi/content/abstract/27/15S/516 . 336. Levine M, Pritchard K, Bramwell V, et al. Randomized trial comparing cyclophosphamide, epirubicin, and fluorouracil with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node-positive breast cancer: update of National Cancer Institute of Canada Clinical Trials Group Trial MA5. J Clin Oncol 2005;23:5166-5170. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16051958 .

Version 2.2015, 03/11/15 © National Comprehensive Cancer Network, Inc. 2015, All rights reserved. The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®. MS-91