NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

doxorubicin/cyclophosphamide (AC)->paclitaxel (T) vs. AC->T with trastuzumab (H) [abstract]. J Clin Oncol 2006;24(Suppl 18):Abstract 581. Available at: http://meeting.ascopubs.org/cgi/content/abstract/24/18_suppl/581 . 350. Telli ML, Hunt SA, Carlson RW, Guardino AE. Trastuzumab- related cardiotoxicity: calling into question the concept of reversibility. J 351. Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369:29-36. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17208639 . 352. Spielmann M, Roché H, Delozier T, et al. Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial. J Clin Oncol 2009;27:6129-6134. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19917839 . 353. Chia S, Norris B, Speers C, et al. Human epidermal growth factor receptor 2 overexpression as a prognostic factor in a large tissue microarray series of node-negative breast cancers. J Clin Oncol 2008;26:5697-5704. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19001334 . 354. Gonzalez-Angulo AM, Litton JK, Broglio KR, et al. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller. Clin Oncol 2007;25:3525-3533. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17687157 .

343. Burstein HJ. The distinctive nature of HER2-positive breast cancers. N Engl J Med 2005;353:1652-1654. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16236735 . 344. Joensuu H, Bono P, Kataja V, et al. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. J Clin Oncol 2009;27:5685-5692. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19884557 . 345. Perez EA, Romond EH, Suman VJ, et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011;29:3366- 3373. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21768458 . 346. Gianni L, Dafni U, Gelber RD, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. 347. Perez EA, Suman VJ, Davidson NE, et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol 2008;26:1231-1238. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18250349 . 348. Tan-Chiu E, Yothers G, Romond E, et al. Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol 2005;23:7811-7819. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16258083 . 349. Geyer CE, Jr., Bryant JL, Romond EH, et al. Update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential Lancet Oncol 2011;12:236-244. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21354370 .

J Clin Oncol 2009;27:5700-5706. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19884543 .

355. O'Sullivan C, Holmes E, Spielmann M, et al. The prognosis of small HER2+ breast cancers: A meta-analysis of the randomized trastuzumab trials [abstract]. San Antonio Breast Cancer Symposium Meeting Abstracts 2013:Abstract S 6-03 Available at:

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