NCCN VERSION 2 2015

NCCN Guidelines Version 2.2015 Invasive Breast Cancer

NCCN Guidelines Index Breast Cancer Table of Contents Discussion

FOLLOW-UP THERAPY FOR ENDOCRINE TREATMENT OF RECURRENT OR STAGE IV DISEASE

No clinical benefit after 3 sequential endocrine therapy regimens or Symptomatic visceral disease

Chemotherapy bbb

Yes

Continue endocrine therapy until progression or unacceptable toxicity

Progression ddd

Trial of new endocrine therapy zz

No

zz See Endocrine Therapy for Recurrent or Stage IV Disease (BINV-M) . bbb See Chemotherapy Regimens for Recurrent or Metastatic Breast Cancer (BINV-N) . ddd See Principles of Monitoring Metastatic Disease (BINV-O) .

Note: All recommendations are category 2A unless otherwise indicated. Clinical Trials: NCCN believes that the best management of any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged.

BINV-22

Version2.2015, 03/11/2015© National Comprehensive Cancer Network, Inc. 2015,All rights reserved.The NCCN Guidelines ® and this illustration may not be reproduced in any form without the express written permission of NCCN ® .