Gynae BT_Lucknow_2018

4 R’s of radiobiology

• Repair – Repair of sub-lethal DNA damage • Redistribution – Radiosensitivity depends on phase in the cell cycle → redistribution changes radiosensitivity • Repopulation – Cell divide during a radiotherapy treatment • Reoxygenation – Radiosensitivity changes due to change in oxygenation