Gynae BT_Lucknow_2018

Randomised trial IMRT versus 3D CRT, TMH

A Phase II Randomized Trial Comparing Intensity Modulated Radiation Therapy (IMRT) with Conventional Radiation Therapy in Stage IIB Carcinoma Cervix (NCT00193804/TMH/158/2004): November 2004

100 patients Conventional External RT (40 Gy /20#) + ICA – HDR (7 Gy x 5#) with Concomitant Chemo-radiation

100 patients IMRT Pelvis (50 Gy/25#) + ICA – HDR (7 Gy x 5#) with Concomitant Chemo-radiation

Hypothesis

• IMRT reduces acute and late RT toxicity’s by 15-25%

• Accrual period 5 years, finished

•However, 10 Gy more in IMRT arm