AOAC Emerging Topics Meeting Book (March 14, 2019)

Mutation Rates

Organism Substitution Rate* E. Coli 4.5 x 10 -9 Salmonella 1x10 -10 Listeria 5x10 -10

*per bp per generation

• Key Questions: • Time dependence, and Statute of Limitations • Convergent Evolution • Environmental conditions

1. Orsi, Renato H et al. “Short-term genome evolution of Listeria monocytogenes in a non-controlled environment” BMC genomics vol. 9 539. 13 Nov. 2008, doi:10.1186/1471-2164-9-539 2. Short-Term Signatures of Evolutionary Change in the Salmonella enterica Serovar Typhimurium 14028 Genome Tyler Jarvik, Howard Ochman Journal of Bacteriology Dec 2009, 192 (2) 560-567; DOI: 10.1128/JB.01233-09