Basic Clinical Radiobiology 2017

Radical scavenging/detoxification Targeting Free Radical Production

10 20 30 40 50 60 70 80 90 100

Amifostine week 2

Amifostine week 1

p=0.0099

s.c.

oral mucosa, mouse ulcer induction

i.v.

co.

p=0.0014

Frequency of responders [%]

10x3 Gy / 2 weeks

Top-up dose [Gy] 0 2 4 6 8 10 12 14 16 18 0

0 2 4 6 8 10 12 14 16 18

Top-up dose [Gy]

Fleischer and Dörr, Strahlenther. Onkol. 182, 2006, 567-575