Basic Clinical Radiobiology 2017

Combined chemo- and radiotherapy treatment

• Spatial co-operation (e.g. breast carcinoma) • Independent cell kill (e.g. Hodgkin lymphoma) • Interaction (e.g. H&N, cervix, NSCLC) • “diluted” toxicity (e.g. Hodgkin lymphoma)

ESTRO 2017

Stage I and II Hodgkin disease (very favorable and favorable categories)

RT

CH

CH+RT (IF, ≤ 40 Gy)

(EF, 40 Gy) (MOPP/ABVD)

10 y over. survival Complications (RR) -leukemia

80-90% 80-90% ≈90%

11.0 21.0

70.0 22.0

reduced reduced reduced reduced

-lymphoma -solid tumor

2.8

1.1

-cardiac

2.2-3.1

≈1.0

ESTRO 2017