Basic Clinical Radiobiology 2017

DOSE MODIFICATION FACTOR IN SA-NH TUMOR AFTER SINGLE IRRADIATION COMBINED WITH FLUDARABINE (800 mg/kg)

10 12 14 16 18 20 22 24

Absolute Growth Delay DMF = 1.57

Normalized Growth Delay DMF = 1.2

GROWTH DELAY ± SE (days) 6 8 RT alone

RADIATION DOSE (Gy) 19 20 21 22 23 24 25 26 27 28 29

ESTRO 2017

Combined chemo- and radiotherapy treatment

D 2D

5

10

15

20

1.0E+00 0

SF 1 2SF 1 SF 2

Supra-additivity?

1.0E-01

S.F.

1.0E-02

1.0E-03

Dose (Gy)

ESTRO 2017