Basic Clinical Radiobiology 2017

Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. M. Morris et al, NEJM, 340:1137-1143, 1999.

Effect on tumor control

5 4 3 2 1 2 3 4 5

Local relapse

Late

Early

Effect on normal tissue toxicity

Enhancement factor

ESTRO 2017

Treatment of advanced squamous-cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. M. Merlano et al, NEJM, 327:1115-1121, 1992.

Effect on tumor control

2

Local relapse

?

1

Early

Late

2

Effect on normal tissue toxicity

Enhancement factor

RT: 70 Gy, 7 weeks RT+CH: 3 x 20 Gy, 9 weeks;

ESTRO 2017

cddp (20mg/m 2 /d, d1-5)-5Fu (200 mg/m 2 /d, d1-5) x4