Basic Clinical Radiobiology 2017

Introduction

• Changes in normal tissue tolerance with time

recovery kinetics

repopulation long-term restoration

160

Long-term recovery from radiation injury in some tissues (not all!)

140

120

100

spinal cord

80

60

Isoeffective dose (Gy)

40

oral mucosa

20

0 0.00001 0.0001 0.001 0.01 0.1

1

10

100

Time interval (days)