Basic Clinical Radiobiology 2017

• Toxicity of initial treatment must be considered, independently of blood cell counts that may be misleading! Earlier recovery of peripheral cell number does not reflect recovery of stem cell population ( i.e. restoration of radiation tolerance)

peripheral cells

peripheral cells

stimulated transit proliferation

stimulated transit proliferation

stem cells

stem cells

relative cell number

relative cell number

time

high dose/toxicity

time

low dose/toxicity