Basic Clinical Radiobiology 2017

Head & neck

100

• Risk of late damage is higher in retreated patients… • But cumulative total dose for 20%

Single course N = 3635

80

60

complication rate at 5 y is higher than predicted from single course treatment (EQD2 3 = 86 vs 67 Gy) indicating partial recovery!

40

Reirradiation N = 487

20

Complication free survival (%)

0

6

8

10

0

2

4

Time from (re)irradiation (years)

Lee AWM et al. Int J Radiat Oncol Biol Phys 20000