Basic Clinical Radiobiology 2017

Head & neck

• Head & neck reirradiation: selection criteria – Patient related considerations

• No severe sequelae of previous radiation treatment • No significant comorbidities • PET-CT is suggested for staging • Interval between RT courses: at least 6 months, preferably longer (1y) • Better prognosis: – Previous surgery – Small (<30cm³) tumor size; caution with bulky tumors (>60cm³) – True second primary tumors (as compared to recurrences) – Tumors in nasopharynx and larynx – EGFR expression/HPV status: uncertain (needs to be evaluated in the context of re-irradiation)

Cacicedo Cancer Treatment Reviews 2014