Basic Clinical Radiobiology 2017

Prostate Brachytherapy is a feasible salvage option for pts with local recurrences after initial RT for prostate cancer • Toxicity fairly high

Ramey World J Urol 2013

Treatment Modality, dose a

Number of patients

Fistula formation (%)

Study

GU Grade 1–2

GU Grade 3–4

GI Grade 1–2

GI Grade 3–4

Incontinence (%)

ED (%)

(%)

(%)

(%)

(%)

Butler et al. [35]; Teh et al. [31]

30

Au 198 , 20 Gy

A-37

0

A-13

0

NR

NR

NR

L-7

L-3

Wong et al. [34]

17

I 125 , 127-139 Gy Pd 103 , 119 Gy

53

47

65

6

18 b

NR

0

I 125 , 137 Gy Prospective studies needed to better define efficacy and toxicity NR 20 14 NR 20 12 NR HDR, 36 Gy/6 fractions I 125 /Pd 103 , 90–112.5 Gy 14 0 92 25

Nguyen et al. [30] Lee et al. [26] Allen et al. [18] Lee et al. 27 Tharp et al. [32]

25 21 12 21

13

86 42 29 71

0 0 0 0

0 0 0 0

0 0

0 5

NR NR 100

Pd 103 , 90 Gy

NR

7

HDR, 6-9 Gy/2-6 fractions ?

29 c

14

29

I 125 /Pd 103 , 72 Gy

Aaronson et al. [17] 24

33

0

8

4

4

NR

0

Burri et al. [20]

37

Pd 103 , 110 Gy I 125 , 135 Gy

32

8

5

3

5

75

3

Moman et al. [29]

31

I 125 , 145 Gy

A-87 L-55

A-3

A-55 L-51

A-0 L-6

NR

NR

6

L-19

Jo et al. [24]

11

HDR, 22 Gy/2 fractions

‘‘Low’’

0

0

0

0

NR

0