Basic Clinical Radiobiology 2017

Regrowth delay assay

• Comparison of growth curves of treated and untreated tumors gives the delay caused by treatment • Relationship between growth delay and surviving fraction of stem cells is complex • Regrowing cells have different environment: surrounded by dead and dying cells; vascular network is already in place

Growth Kinetics of Tumors, G.G. Steel, 1977

• Tumor bed effect