Basic Clinical Radiobiology 2017

Radiobiological mechanisms underlying the dose rate effect

Time to give 2 Gy

100 h

10 h

1 h

10 min

1min

Repopulation

Reoxygenation

Redistribution

Repair

Modified from Steel et al (1986)

LDR MDR HDR

0.01

0.1

1

10

100

1000

Dose rate (cGy/min)