Basic Clinical Radiobiology 2017

a/b -value - late effects / experimental data Tissue / reaction a/b -value [Gy] Ref. Dose fractionation: LQ formalism

van der Kogel 1979 White and Hornsey 1978 Ang et al. 1983 Thames et al. 1981 van der Kogel 1979 White and Hornsey 1978 Leith et al 1981 Amals and Yuhas Terry and Denekamp Trott and Kummermehr 1994 Caldwell 1975 Hopewell and Wiernik 1977 van Rongen et al. 1988

Spinal cord cervical

1.8-2.7 1.6-1.9 1.5-2.0 2.2-3.0 3.7-4.5 4.1-4.9 3.8-4.1 2.3-2.9 3.1-5.0 1.7-2.0 1.7-2.0 0.5-3.8 1.0 0.9-2.8 1.4-4.3

lumbar

Weight loss Rectal stenosis

Intestine

Kidney

liams and Denekamp 1984

Stewart et al. 1984 Thames et al. 1988

Stewart et al. 1984 Bentzen et al. 1992 Dörr and Bentzen 1999 Wara et al. 1973 Field et al 1976 Travis et al. 1983 Parkins and Fowler 1985

Urinary bladder Impaired function

6.6 [2.2;14.5] 5.8 [3.6;8.8] 4.4 [2.0;8.4]

LD50

Lung

4.4-6.3 2.8-4.8 2.0-2.4 1.9-3.1

Breathing frequency

ESTRO BCR Course / NT radiosensitivity and fractionation – W. Dörr