Basic Clinical Radiobiology 2017

Conventional fractionation 1.8 – 2.0 Gy per fraction, 5 fractions per week IIIII IIIII IIIII IIIII IIIII IIIII IIIII

Example

Dose (Gy)

Tumor control (%)

Seminoma, Lymphoma

£ 45

³ 90

Sensitive

SCC, Adeno-Ca

50 60 70

³ 90 (subclinical) ~ 85 (Ø 1 cm) ~ 70 (Ø 3 cm) ~ 30 (Ø 5 cm)

Intermediate

Glioblastoma Melanoma

³ 60 ≥ 60

none? none?

Resistant

ESTRO 2017

Prototypes of modified fractionation

• Hyperfractionation (HF) • Accelerated fractionation (AF)

• (Hybrid schedules) • Hypofractionation

ESTRO 2017