Palliative care 2017

Opioid tolerance in advanced cancer patients

Open label multicenter study (Fen-Bel 5 study) compassionate use TTS-fentanyl in Belgium (59 physicians)

Palliative untreatable cancer patients with a assessed life expectancy of ≥ 3 months that need opioids for pain relief could be included (inform. cons)

After stabilisation (14d) on oral morphine  VAS-score <3,5 Change of morphine  equivalent dose TTS-fentanyl, oral morphine is free available for break through pain (BTP) Dose fentanyl is up-titrated if oral morphine ≥ 60mg/d for BT

Aim of the study: compliance + side effects of TTS fentanyl