SPIFAN SP Meeting September 17, 2016

Conclusions of SLV • 5-CHO-THF quantified in soy-based formulas, after conjugase treatment up to | 10% of total folates • 5-MTHF quantified in milk-based formulas, after conjugase treatment up to | 14% of total folates • THF, 10-CHO-FA, 10-CH3-FA < LOQ • 5,10-CH=CH-THF in one milk-based sample < 6.5% total folates, not confirmed in SLV 2

Motion Adapt SMPR Applicabilty Statement in:

Determination of total folate [supplemental folic acid or 5-methyl-tetrahydrofolate, 5- formyl-tetrahydrofolate and endogenous 5-methyl-tetrahydrofolate polyglutamate, and 5-formyl tetrahaydrofolate polyglutamate ] in all forms (powders, ready-to-feed liquids, and liquid concnetrates) of infant, adult, and pediatric nutritional formula.

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