BPS Program Book 2014

577-P os B oard #B332 PHOSPHORYLATION OF MAUROCALCINE STRONGLY MODIFIES ITS EFFECT ON TYPE 1 RYANODINE RECEPTOR. Wei Feng , Michel Ronjat, Yao Dong, Eloi Bahembera, Michel De Waard, Isaac N. Pessah 578-P os B oard #B333 EFFECTS OF AMINO-TERMINAL DISEASE-ASSOCIATED MUTATIONS ON THE CICR ACTIVITY OF RYR1 CHANNEL. Takashi Murayama , Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Shigeru Takemori, Katsuji Oguchi, Takashi Sakurai 579-P os B oard #B334 FUNCTIONAL ANALYSIS OF RYANODINE RECEPTOR CARRYING MALIGNANT HYPERTHERMIA ASSOCIATED MUTATIONS. Toshiko Yamazawa , Takashi Murayama, Hideto Oyamada, Junji Suzuki, kazunori Kanemaru, Nagomi Kurebayashi, Shigeru Takemori, Masamitsu Iino 580-P os B oard #B335 MALIGNANT HYPERTHERMIA ASSOCIATED MUTATIONS IN S2-S3 LOOP OF TYPE 1 RYANODINE RECEPTOR CALCIUM CHANNEL ALTER CALCIUM DEPENDENT INACTIVATION. Angela C. Gomez, Timothy Holford, Naohiro Yamaguchi 581-P os B oard #B336 RYANODINE RECEPTOR INTERACTION WITH FKBP12 IS MODULATED BY THE RYR N-TERMINUS REPEAT REGION. Polly Marino, F. Anthony Lai , Lynda Blayney 582-P os B oard #B337 MODULATION OF RYANODINE RECEPTORS AND THE CA 2+ ATPASE OF SARCOPLASMIC RETICULUM BY ANTIEPILEPTIC AGENTS. Yuanzhao Lv , Paula L. Diaz-Sylvester, Julio A. Copello 583-P os B oard #B338 C. ELEGANS AS A MODEL TO STUDY RYANODINE RECEPTOR FUNCTION IN AGING. Alisa Umanskaya , Daniel Andersson, Wenjun Xie, Steven Reiken, Andrew Robert Marks Calcium Signaling I (Boards #B339–#B363) 584-P os B oard #B339 PHOSPHODIESTERASE EXPRESSION PATTERN AND ACTIV- ITY PARTITIONING IN LIPID RAFT AND IN NON-LIPID-RAFT MICROENVIRONMENT IN CARDIAC SINOATRIAL NODAL CELLS. Antoine Younes, Yevgeniya Lukyanenko , Alexey Lyashkov, Kirill Tarasov, Syevda Sirenko, Bruce Ziman, Magdalena Juhaszova, David R. Graham, Edward G. Lakatta 585-P os B oard #B340 CA 2+ CYCLING PROTEINS PHOSPHORYLATION IN ISOLATED SINOATRIAL NODAL CELLS MODULATES THE STOCHASTICITY OF SPONTANEOUS DIASTOLIC LOCAL CA 2+ RELEASES WHICH REGULATE THE ACTION POTENTIAL CYCLE LENGTH AND ITS BEAT-TO-BEAT VARIATION. Dongmei Yang , Alexey E. Lyashkov, Bruce D. Ziman, Edward G. Lakatta 586-P os B oard #B341 COUPLED-CLOCK PACEMAKER SYSTEM BECOMES DYSFUNCTIONAL WITH AGING. Syevda Sirenko, Magdalena Juhaszova, Jie Liu, Ismayil Ahmet, Steven J. Sollott , Edward G. Lakatta 587-P os B oard #B342 CONTRIBUTION OF CA-REGULATED ION CURRENTS TO THE ACTION POTENTIAL MORPHOLOGY DURING CARDIAC ALTERNANS. Giedrius Kanaporis , Lothar A. Blatter

566-P os B oard #B321 MOLECULAR MODELING AND STRUCTURAL DOCKING OF A RYANODINE RECEPTOR SPRY2 DOMAIN. Li Zhu, Ruiwu Wang, S. R. Wayne Chen, Terence Wagenknecht, Zheng Liu 567-P os B oard #B322 A REGULATORY COMPONENT OF THE HUMAN RYANODINE RECEPTOR 2 N-TERMINUS. Lubomir Borko, Vladena Bauerova-Hlinkova, Alexandra Zahradnikova , Julius Kostan, Konrad Beck, Juraj Gasperik, Eva Hostinova, F. Anthony Lai, Jozef Sevcik 568-P os B oard #B323 DIVERGENT EFFECTS OF DISEASE-ASSOCIATED MUTATIONS CRYSTAL STRUCTURE OF CARDIAC RYANODINE RECEPTOR N-TERMINAL REGION CONTAINS UNIQUE ANION BINDING SITE TARGETED BY DISEASE-ASSOCIATED MUTATIONS. Lynn Kimlicka , Ching-Chieh Tung, Anna-Carin C. Carlsson, Paolo A. Lobo, Zhiguang Yuchi, Filip Van Petegem 570-P os B oard #B325 ARRHYTHMOGENIC MECHANISMS IN CATECHOLAMINER- GIC POLYMORPHIC VENTRICULAR TACHYCARDIA LINKED TO RYR2 LOSS-OF-FUNCTION MUTATION. Yan-Ting Zhao , Carmen R. Valdivia, Georgina B. Gurrola, Cong Li, Patricia P. Powers, Héctor H. Valdivia 571-P os B oard #B326 PREVENTING RYR2-S2808 AND RYR2-S2814 PHOSPHORYLATION DOES NOT ALTER THE β -ADRENERGIC RESPONSE OF MOUSE HEARTS. Emmanuel Camors , Randall Loaiza, Francisco Alvarado, Yanting Zhao, Patricia Powers, Hector H. Valdivia 572-P os B oard #B327 SUPPRESSED RYR2 FUNCTION REPRESENTS A COMMON CAUSE OF IDIOPATHIC VENTRICULAR FIBRILLATION AND SUDDEN CARDIAC DEATH. Xiaowei Zhong , Yijun Tang, Ruiwu Wang, Vern Hsen Tan, Yingjie Liu, Lin Zhang, Carlo Napolitano, Silvia Priori, SuiRong Wayne Chen 573-P os B oard #B328 SUPPRESSION OF SPONTANEOUS CA 2+ RELEASE BY CARDIOPROTECTIVE DRUGS. Jingqun Zhang , Chris D. Smith, Qiang Zhou, Jianmin Xiao, Guogen Wu, Alma Nani, Thomas G. Back, Michael Fill, S.R. Wayne Chen 574-P os B oard #B329 CRYO-EM STUDIES OF RYR1 CHANNEL IN DETERGENT-FREE AQUEOUS ENVIRONMENT. Olga B. Popova , Guizhen Fan, Mariah R. Baker, Joanita Jakana, Wah Chiu, Steven J. Ludtke, Irina I. Serysheva 575-P os B oard #B330 LIGAND-INDUCED CONFORMATIONAL CHANGES IN TETRA- MERIC IP3R1 REVEALED BY SINGLE-PARTICLE CRYO-EM. Guizhen Fan , Olga B. Popova, Steven J. Ludtke, Irina I. Serysheva 576-P os B oard #B331 COUPLED GATING OF RYANODINE RECEPTORS: EVIDENCE FOR A ROLE OF PHYSICAL RYR-RYR INTERACTIONS. Paula L. Diaz-Sylvester , Jake T. Neumann, Sidney Fleischer, Julio A. Copello ON TYPE 2 RYANODINE RECEPTOR CHANNEL. Nagomi Kurebayashi , Takashi Murayama, Akira Uehara, Midori Yasukochi, Takashi Sakurai 569-P os B oard #B324

40

Biophysical Society 58 th Annual Meeting, San Francisco, California