BPS Program Book 2014

Voltage-gated K Channels I (Boards #B457–#B486)

714-P os B oard #B469 IN KCNQ1 CHANNELS, A LONG QT MUTATION INDUCES A REGULATION BY CHOLESTEROL INSTEAD OF PHOSPHATI- DYLINOSITOL-4,5-BISPHOSPHATE. Fabien C. Coyan , Mohamed-Yassine Amarouch, Fayal Abderemane Ali, Julien Piron, Jérome Mordel, Céline S. Nicolas, Marja Steenman, Jean Mérot, Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró, Gildas Loussouarn 715-P os B oard #B470 A PAIR OF PHENYLALANINE RESIDUES ON THE S4 AND S5 SEGMENTS CREATE A PHYSICAL AND ENERGY BARRIER FOR THE VOLTAGE SENSOR IN KCNQ1/KCNE1 CHANNEL. Koichi Nakajo , Yoshihiro Kubo 716-P os B oard #B471 ENDOPLASMIC RETICULUM SAC1 4-PHOSPHATASE REDUCES PLASMA MEMBRANE KCNQ2/3 CURRENTS. Eamonn J. Dickson , Jill B. Jensen, Bertil Hille 717-P os B oard #B472 KCNQ1 EXPRESSION MODULATES HERG CURRENT BY REMOVING INACTIVATION. Carlos G. Vanoye , Richard C. Welch, Alfred L. George 718-P os B oard #B473 INTERACTION BETWEEN KCNQ1 GAIN-OF-FUNCTION RESIDUES. Carlos G. Vanoye , Richard C. Welch, Brett M. Kroncke, Alfred L. George, Charles R. Sanders 719-P os B oard #B474 MODULATION OF K V 2.1 AND K V 2.1/K V 6.4 CHANNELS BY AUXILIARY KCNE SUBUNITS. Elke Bocksteins , James S. Trimmer, Dirk J. Snyders 720-P os B oard #B475 A NOVEL COMPOUND TARGETING KV7.2/3 CHANNELS RELIEVES INFLAMMATORY AND NEUROPATHIC PAIN. Asher S. Peretz , Eti Patrich, Polina Kornilov, Nataly Menaker, Bernard Attali 721-P os B oard #B476 I KS ACTIVATORS SHIFT THEIR BINDING SITES IN THE KCNQ1 CHANNEL AFTER KCNE1 ASSOCIATION - IN SILICO PREDICTIONS AND EXPERIMENTAL TESTS. Yu Xu , Yuhong Wang, Mei Zhang, Min Jiang, Gea-Ny Tseng 722-P os B oard #B477 CALCIUM-INDEPENDENT POTENTATION OF KV7.2 CURRENT DENSITY BY CALMODULIN. Carolina Gomis-Perez , Virginia Soldovieri, Araitz Alberdi, Paolo Ambrosino, Alessandro Alaimo, Ganeko Bernardo-Seisdedos, Pilar Areso, Maurizio Taglialatela, Alvaro Villarroel 723-P os B oard #B478 KV7.2/7.3 CHANNELS ARE ENHANCED DURING STRIATAL DEVELOPMENT AND PROMOTE NEURONAL FUNCTIONAL MATURATION OF IPS CELL-DERIVED NEURONS. Vsevolod Telezhkin , Belinda A.N. Thompson, Monica Pardo, Gerardo Garcia-Diaz Barriga, David A. Brown, Josep M. Canals, Nicholas D. Allen, Paul J. Kemp 724-P os B oard #B479 TAMOXIFEN INHIBITION OF KV7.2/KV7.3 CHANNELS. Tania Ferrer , Iván Arael Aréchiga Figueroa, Mark S. Shapiro, Martin Tristani-Firouzi, José A. Sánchez-Chapula

702-P os B oard #B457 HIGH YIELD EXPRESSION OF THE HUMAN ETHER-à-GO-GO RELATED GENE (HERG) IN SACCHAROMYCES CEREVISIAE . Karen Molbaek , Peter Scharff-Poulsen, Dan A. Klaerke, Per Amstrup Pedersen 703-P os B oard #B458 education travel awardee EXPRESSION AND PURIFICATION OF A FUNCTIONAL HERG PORE DOMAIN FOR BIOPHYSICAL AND ELECTROPHYSIOLOGICAL STUDIES. Maïwenn Beaugrand , Sumit Kalsi, Andrée E Gravel, Christopher D. Johnson, Neville Wright, Jason C Young, Maurits R. R. de Planque, Isabelle Marcotte, Philip T. F. Williamson 704-P os B oard #B459 EAG DOMAINS REGULATE LQT MUTANT HERG CHANNELS IN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES. Qiangni Liu , Matthew C. Trudeau 705-P os B oard #B460 THE ROLE OF THE CYCLIC NUCLEOTIDE BINDING HOMOLOGY DOMAIN IN VOLTAGE AND CALCIUMDEPENDENT GATING OF EAG POTASSIUMCHANNELS. Eva Loerinczi , Avril Newman, Sophie Draycott, Frederick W. Muskett, John S. Mitcheson 706-P os B oard #B461 INSIGHTS INTO MOLECULAR BASIS OF HERG INHIBITION BY STUDYING A LIBRARY OF DOFETILIDE DERIVATIVES. Priyanka Saxena , Tobias Linder, Anna Stary-Weinzinger, Adriaan P IJzerman, Eugen Timin, Gerhard Franz Ecker, Steffen Hering 707-P os B oard #B462 SENSITIVITY OF FLECAINIDE INHIBITION OF HERG CHANNELS TO CHANNEL INACTIVATION. Dario Melgari , Aziza El Harchi, Cristopher E. Dempsey, Jules C. Hancox 708-P os B oard #B463 HIGH AFFINITY BLOCK OF HERG1 CHANNELS IS WEAKLY DEPENDENT ON INACTIVATION. Wei Wu 709-P os B oard #B464 cpow travel awardee INVERSTIGATING STEREOSELECTIVITY OF PHARMACOLOGICAL INHIBITION OF HERG CHANNELS. Yi H. Zhang , Aziza EI Harchi, Christopher E. Dempsey, Jules C. Hancox 710-P os B oard #B465 REGULATION OF HERG C-TERMINAL ISOFORM EXPRESSION BY MODIFIED U1 SMALL NUCLEAR RNA. Qiuming Gong , Matthew R. Stump, Zhengfeng Zhou 711-P os B oard #B466 HERG CHANNEL VOLTAGE SENSOR MOVEMENT PRECEDES PORE OPENING. Samuel J. Goodchild , David Fedida 712-P os B oard #B467 INTERACTIONS OF EXTRACELLULAR DIVALENT IONS AND HYDROGEN WITH THE OUTER PORE OF THE CARDIAC POTASSIUM CHANNEL HERG. Chris Yoon, Scott Loeb, Peter Nilsson, Alan Miller 713-P os B oard #B468 A SALT BRIDGE LINKS CNBHD CONFORMATION TO THE GATING MACHINERY IN EAG POTASSIUM CHANNELS. Yaxian Zhao , Phu Tran, Joao Morais Cabral, Gail A. Robertson

46

Biophysical Society 58 th Annual Meeting, San Francisco, California