PracticeUpdate: Haematology & Oncology

1,2 EASY TO MISS IMPOSSIBLE TO IGNORE

To diagnose Paroxysmal Nocturnal Haemoglobinuria (PNH), clinical suspicion and accurate testing are essential 1,2

PNH in patients with haemolysis, bone marrow dysfunction and unexplained thrombosis 1 SUSPECT

with accuracy using high sensitivity flow cytometry on red blood cells (RBCs) and white blood cells (WBCs) 1 TEST

regularly, using flow cytometry in at-risk patients and patients with a PNH clone 1,2 MONITOR

For more information on flow cytometry testing guidelines, visit www.testingforpnh.com.au • PNH case study data show that the diagnosis of PNH continues to be delayed 3-5 • In patients belonging to at-risk groups, flow cytometry testing is essential 1,2,6-15 At risk groups: Haemolysis = Coombs (-) haemolytic anaemia; Haemoglobinuria & haemosiderinuria; Renal dysfunction. Bone Marrow Dysfunction = Aplastic anaemia, MDS & cytopenia. Unexplained Thrombosis = Venous and arterial.

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