Biophysical Society Thematic Meeting | Singapore

Mechanobiology of Disease

Poster Abstracts

61-POS Board 61 Particle-based Modeling and Simulation of Cells in Flow Kirill Lykov 1 , Yasaman Nematbakhch 2 , Chwee Teck Lim 2 , Igor V. Pivkin 1 . 1 University of Lugano, Lugano, Switzerland, 2 National University of Singapore, Singapore, Singapore. We developed a computational framework for simulations of red blood cells in fluid domains using particle-based Dissipative Particle Dynamics (DPD) method. The use of DPD provided a unified way to describe fluid, fluid-structure and structure-structure interactions. The framework was employed in simulation of a wide range of blood rheology problems, such as analysis of the flow in the lab-on-a-chip devices and studies of cell transport in the microvascular networks. We recently extended the framework by developing a new model for cells with nucleolus, such as white blood cells and circulating tumor cells. We will present the new cell model and its validation using quantitative data from microfluidic experiments.

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