AOAC SPADA February 2015 Meeting Book

Stakeholder Panel on Agent Detection Assays SPADA MEETING 15

03 FEB 2015

Matthew G. Davenport, Ph.D. SPADA Ch i a r The Johns Hopkins University Applied Physics Laboratory

James Bradford Executive Director AOAC INTERNATIONAL

1

SPADA Objectives & History  Original Objectives in 2007 - Establish standards to validate Polymerase Chain Reaction (PCR)-based technologies that detect aerosolized Bacillus anthracis , Yersinia Pestis , or Francisella tularensis - Pilot the validation process with an assay that detects B. anthracis  2009 D l d d lid i b d H d H ld A (HHA ) h d - eve op stan ar s to va ate mmunoassay- ase an - e ssays s t at etect B. anthracis or Ricin in suspicious powders - Test commercially-available HHAs  2010 - Develop standards to validate PCR-based technologies that detect aerosolized Burkholderia psuedomallei and Burkholderia mallei - Develop standards to validate PCR-based technologies that detect B. anthracis in suspicious powders  2011 - Develop recommendations on controls needed for field-based assays  2013 - Develop standards to validate PCR-based technologies that detect aerosolized Variola - Establish First Responder Working Group - Maintain a SPADA Executive Steering Committee  2014 - Establish standards to validate technologies that detect Venezuelan Equine Encephalitis Virus, Staphylococcus Entertoxin B, and Coxiella burnetti (Q-fever)

2