AOAC SPADA February 2015 Meeting Book

Laboratory probability of detection (LPOD) POD value obtained from combining all valid collaborator data  sets for a method for a given matrix at a given analyte level or  concentration. False‐negative rate Proportion of test results that are negative, contained within a  population of known positives. False‐positive rate Proportion of test results that are positive, contained within a  population of known negatives.

Predictive value (negative) The probability that an animal is free from exposure or infection given that  it tests negative; predictive values are a function of the DSe (diagnostic  sensitivity) and DSp (diagnostic specificity) of the diagnostic assay and the  prevalence of infection. Predictive value (negative) The probability that an animal has been exposed or infected given that it  tests positive; predictive values are a function of the DSe and DSp of the  diagnostic assay and the prevalence of infection. Sensitivity (analytical) Synonymous with “Limit of Detection‟, smallest detectable amount of  analyte that can be measured with a defined certainty; analyte may  include antibodies, antigens, nucleic acids or live organisms.