AOAC SPADA February 2015 Meeting Book

General Analytical Needs

• Infectious dose for humans 10‐100  organisms • Diagnostic testing via PCR – To date, no real time PCR for VEE  published • Need to include Subtypes IAB and IC • Ideal to exclude other Subtypes and  serotypes (ID, IE, IF, II, III, IV, V) • Need to distinguish EEE, WEE, VEE

VEEV is an Overlap Select Agent USDA/HHS Regulations  • Includes VEEV Subtypes IAB and IC only  • Any subtypes of Venezuelan equine encephalitis  virus except for Subtypes IAB or IC are excluded from Select Agent status provided that the ,  individual or entity can verify that the agent is  within the exclusion category. – TC‐83 vaccine strain and vaccine candidate strain  V3526 are excluded from Select Agent Regulations