AOAC SPADA February 2015 Meeting Book

A A Q Fever Pneumonia: Guinea pig model PBS Cont rol 1 2 3 A

B 2

B 3

B 1

7 da ys p.i. 28 day

C 1

C 2

C 3

s p.i. 28 days p.i., vaccina ted

D 1

D 2

D 3

C. burnetii infection leads to pneumonia at high doses. 7d pi – panleukocytic bronchointerstitial pneumonia 28d pi – lymphohistiocytic interstitial pneumonia

Formalin inactivated Whole Cell  Vaccine (WCV) Q-vax ® : Effective Q fever vaccine licensed for used in Australia Long-lived, single dose Not FDA approved: IND material Serious side effects in previously sensitized individuals (local and systemic) Requires pre-screening: Skin test and phase I/phase II serology

 Next generation vaccines under  development