AOAC SPADA February 2015 Meeting Book

STAKEHOLDER PANEL ON Agent  Detection Assays Background & Fitness for Purpose Staphylococcal enterotoxin B

Sandra Tallent, PhD h b l Researc Micro io ogist  US FDA AOAC Rockville, MD February 3, 2015

Background on Staphylococcal enterotoxins • Pyrogenic exoproteins • Stable proteins – Water soluble – Heat resistant – Protease resistant – Tolerate extreme pH changes • Twenty‐three homologous serologically distinct  SEs identified • SEA‐SEE select agent status • Superantigenic