AOAC SPADA February 2015 Meeting Book

Aerosol exposure • Based upon accidental laboratory inhalation  exposure • Symptoms noted within 90 minutes‐24 hours  after exposure • Symptomatic 3‐4 days – Fever – Headache – Muscle aches – Pulmonary symptoms – GI symptoms

Superantigenic properties of SEs • Cross link T‐cells with Antigen Presenting Cells • By‐passing antigen processing • Activates large populations of T‐cells • Release of cytokines T i h k d t • ox c s oc syn rome symp oms • Fever, hypotension vomiting, diarrhea, rash, renal failure • Associated with SEA, SEB, and SEC