AOAC SPADA February 2015 Meeting Book

SEs as biothreat agents

• Universal availability • Ease of production and dissemination • Potentially could cause widespread illness

• Common in the environment • Diseases are similar to others l l l • Initia aeroso ization researc per orme on SEB on y • SEA & SEC shown later to have similar effects h f d

Category B biothreat agent

• Low mortality/High morbidity • Easily disseminated in a crowd incapacitating  hundreds • Amount SEB required less than synthesized chemicals – ~400 pg/kg body weight incapacitates 50% human  population exposed to aerosol attack • 175 pound person ~32 ng – ~200 ng/kg body weight would be lethal for 50% human  population exposed to aerosol attack • 175 pound person ~15,800 ng