Gynae BT 2017

With increasing dose to the recto-vaginal reference point, the probability of vaginal stenosis G≥2 increases significantly (p=0.003). Stenosis: ICRU recto- vaginal referene point

Based on the model curve, the risk was 20% at 65Gy, 27% at 75Gy and 34% at 85Gy (recto-vaginal reference point dose).

Keeping the EBRT dose at 45Gy/25fractions and decreasing the dose contribution of brachytherapy to the vagina decrease the risk of stenosis.

A planning aim of ≤65Gy EQD2 (EBRT+brachytherapy dose) to the recto-vaginal reference point is therefore proposed.

Kirchheiner et al. RO 2016