Gynae BT 2017

Bone Marrow

Around 50% of adult BM located in lower L spine and pelvic bones

• Red BM is active compartment • High sensitivity for radiation

• Repopulation capability

Pelvic RT

 White blood cell count  Hemoglobin  Platelet count

Concomitant ChT increases BM toxicity

Mell LK. IJROBP 2006 Sacks EL. Cancer 1978 Rubin P. Cancer 1973

Brixey CJ. IJROBP 2002 Lujan AE. IJROBP 2003 Fiorino C. Radiother Oncol 2009

Ahmed RS IJROBP 2004 Roeske JC Radiother Oncol 2005