AOAC SPDS Meeting Book March 19 2015

Chemistry and Properties of Aloin: • Yellow‐brown colored  latex constituent. • It is used as a stimulant‐ laxative before 2002. • Treating constipation by  inducing bowel  movements. • Found under the rind of  the aloe leaf and in  between it and the gel. 

Regulations • Approved in the US in 1975 as an OTC drug to treat  chronic constipation, aloe latex is no longer approved for  such US use as of May 9, 2002 • US FDA National Toxicology Program conducted toxicity  study on unpurified (high‐aloin) dry leaf juice • European Council Directive 88/388/EEC of 22 June 1988  ll t 0 1 /k l i f d/b fl i a ows up o . mg g a o n as oo everage avor ng  • Topical use in cosmetics up to 50 ppm of aloin is allowed  (CIR 2007)