Biophysical Society Thematic Meeting| Aussois 2019

Biology and Physics Confront Cell-Cell Adhesion

Poster Abstracts

30-POS Board 30 REGULATE CELL-CELL INTERACTION VIA LIPID-RAFT-TARGETED MOLECULAR ASSEMBLY Guanying Li 1 ; Xunwu Hu 1 ; Ye Zhang 1 ; 1 Okinawa Institute of Science and Technology Graduate University, Bioinspired Soft Matter Unit, Kunigami Gun, Japan Hippo signalling pathway controls multiple cellular functions that are central to tumorigenesis. Its importance in cancer cell proliferation and metastasis has been well recognized. Here we created polypyridyl ruthenium comjugated peptide complex for lipid-raft-targeted molecular assembly. Via hydrolyzation by ovarian cancer biomarker, glycosylphatidylinositol-anchored placental alkaline phosphatase (ALPP), molecules assemble into nanostructures adhere to lipid rafts restricting their dynamics and spatial distributions. Through actin cytoskeleton, the regulation of lipid rafts stimulates Hippo signalling pathway, regulating cell-cell interaction, deactivating the core oncogene YAP in cancer cells suppressing cancer cell migration and inducing cancer cell apoptosis.

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