OMB Meeting Book (March 2, 2017)

OMB Meeting Book

36

Department of Pharmacology, Robert Wood Johnson Medical School-UMDNJ, Piscataway, New Jersey, USA  Performed research in drug discovery and development of anti-AIDS and anti-cancer; Contributed in drug design and structural optimization, drug synthesis and characterization, purification and preformulation  Conducted analytical and bioanalytical method development and validation of drug substance  Performed separation, elucidation and identification of active pharmaceutical ingredient using HPLC, LC-MS/MS, MALDI-TOF MS and NMR  Conducted pharmaceutical analysis of biological samples to evaluate the pharmacokinetics and elucidate the metabolite of organic drug compounds  Conducted pegylation of active pharmaceutical ingredient to increase bioavailability and optimize pharmacokinetics  Performed design and optimization of drug structure to increase inhibition efficacy to fight AIDS  Performed preparative separation to obtain the most active species against AIDS using semi-prep and prep HPLC Mar. 2005 - July 2007 Collaboration scientist Novaflux Biosciences Inc., Princeton, New Jersey, USA  Developed microbicides from homopolymer and copolymer of guanides and their derivatives (PBGs) to prevent HIV-AIDS transmission  Performed preformulation of topical microbicides as the fusion inhibitor of HIV type-1 virus  Investigated the feasible applications of PBGs on other infectious diseases  Conducted the characterization and identification of active pharmaceutical ingredient and drug substance by NMR, HPLC, LC-MS/MS and MALDI-TOF MS Sep.1999 - Dec. 2004 Research and Teaching Assistant Department of Chemistry and Biochemistry, Auburn University, Auburn, AL  Conducted qualitative and quantitative analytical method development and validation with HPLC, HPAEC, IEC, LC-MS, GC-IR, GC-MS, ESI-MS and MALDI-TOF MS  Developed electroactive polymers and completed characterization of their chemical and physical properties by various techniques  Performed isolation and identification of biological samples including proteins, peptides and saccharides  Developed a group of gas sensors with high selectivity and sensitivity for volatile organic compounds (VOCs)  Discovered the polymerization and redox switching mechanism using electrochemistry combined with Electrochemical Quartz Crystal Microgravity  Instructed Instrumental Analysis Lab, Chemical Analysis Lab and General Chemistry Lab; Supervised and trained graduate and undergraduate students July 1993 - Aug. 1999 Process Engineer SINOPEC  Shanghai Engineering Company Limited (SSEC),  Shanghai, P.R.China  Conducted process evaluation and improvement, transferred manufacturing process from R&D to operations  Developed and designed process flow, plant layout, equipment and piping system  Committed ANSI, API, cGMP and FDA requirement for chemical and pharmaceutical industries  Conducted and evaluated on-site installation, troubleshooting, validation, start-up and commission run test

 China Petrolum & Chemical Corporation  Former Shanghai Pharmaceutical Industry Design Institute (SPIDI)

March 2, 2017