OMB Meeting Book (March 2, 2017)

OMB Meeting Book

50

STATEMENT OF EXPERTISE

William Martin

I am writing for your consideration regarding an appointment to the AOAC Expert Review Panel. I am confident that my extensive background in analytical chemistry and method development will provide a diverse expertise that would be well suited for the review panel. My specialties range between spectroscopic analysis, nanotechnology, biological sample preparation, and single molecule detection. This broad range of skills will provide a unique point of view to the review panel. I recently received my Ph.D. in analytical chemistry from the University of Kentucky in the Richards Lab, where I worked to develop cutting edge analytical methods. This includes spectroscopic studies between various pharmaceuticals and the active sites on live cells. The methods developed allowed the study of the flow of nutrients (including potassium, calcium, and other metals) across plasma membrane (PM) of mammalian cells, vesicle fusion for the purposes of drug delivery, and nicotinic receptor stoichiometric. During my tenure as a graduate student I participated in a four month fellowship in the Vosch Lab at the University of Copenhagen. We worked to develop new single molecule confirmation methods via the simultaneous acquisition of six separate spectroscopic signals on an individual fluorophore. This work, when used in conjunction with various nanofabrication methods, allowed me to perform accurate and reproducible characterizations for spectroscopically enhanced biomarkers. During my graduate research fellowship I worked at the Center for Nanophase Materials Sciences at Oak Ridge National Laboratory to develop nanofabrication methods for single particle analysis. These new procedures were simplified and allowed reproducible fabrication of nanostructures that were cost effective. These structures were then used to analyze calcium flux across the PM of cancer cells, biomarker enhancement, and measurement of single ligand turnover in live cells. My current position as Sr. Researcher at Compass Minerals is heavily involved with the method development for macro and micro nutrients in fertilizers. This type of work is closely correlated to very important safety interests outlined by the AOAC. While my industry experience is somewhat limited, I believe my expertise in such a diverse array of analytical methods would make me a great addition to the AOAC Expert Review Panel. I appreciate your consideration and look forward to making a contribution.

Fau CV 

March 2, 2017