SPADA Draft Documents

scenario, a lab routinely engaged in assay development could complete this process within 6-12 66 months. 67 Detection assays are typically designed using all available sequences at that time. Many of 68 the biodefense assays were designed and tested over a period of time at least a decade ago when 69 available sequences were limited. Thanks to recent advances in next generation sequencing 70 technologies there is a sharp increase in the availability of whole genome sequences. Hence, 71 these assays have the potential to fail if evaluated against the currently available sequences 72 (Figure 1).

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75 Figure 1. Availability of whole genome sequences for representative organisms and viruses and 76 assay design time frame.

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