September 2016 SPSFAM Book

9/13/2016

General Analytical Needs

Recognize two basic analytical needs: 1. Quantitative QC method to support product manufacture

a) Quick b) Easy 2. Qualitative method to verify authenticity

Challenges

▪ Recognize four primary challenges in the analysis of cranberry proanthocyanidins 1. Analyte heterogeneity and complexity a) Not a single compound b) Wide range of DP and Isomers

c) Differentiating structural characteristic (A-type versus B-Type) 2. Range of solubility impacts sample preparation and analysis 3. Lack of standards

a) Results differences between methods 4. Achieving methodology consensus

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